Expression of Vascular Endothelial Growth Factor in Nasal Polyp and Chronic Rhinosinusitis

Authors

  • Aida Rostami Dept. of Anatomical Sciences and Pathology, Faculty of Medicine, Shahed University, Tehran, Iran
  • Ali Davati Dept. of Anatomical Sciences and Pathology, Faculty of Medicine, Shahed University, Tehran, Iran
Abstract:

Background: Nasal inflammatory disorders such as chronic rhinosinusitis and nasal polyp are among the most prevalent complications with high socioeconomic costs. Vascular Endothelial Growth Factor (VEGF) plays a key role in angiogenesis and cell proliferation. In the present study the effect of VEGF on the development and prognosis of chronic rhinosinusitis and nasal polyp was investigated. Methods: This cross sectional study was performed on the nasal histological specimens of two groups of patients suffering from nasal polyp or chronic rhinosinusitis, and the expression of VEGF in the two groups was compared immunohistochemically. Based on the percentage of VEGF-positive cells the specimens were classified into four scores. Furthermore, the relations between the VEGF expression and some demographic characteristics were evaluated. Results: The VEGF immunohistochemistry findings indicated a significantly higher expression of VEGF in nasal polyp group compared to chronic rhinosinusitis without nasal polyp group. In terms of VEGF-expression scoring, in both groups most of the specimens were classified as score-2, namely indicating 10-50% of VEGF-positive epithelial cells. In both groups no significant relation between VEGF expression and age or sex of the patients could be seen. Conclusion: Local modulation of VEGF expression might be taken as a putative therapeutic strategy in management of sinunasal inflammatory disorders, especially nasal polyps. 

Upgrade to premium to download articles

Sign up to access the full text

Already have an account?login

similar resources

expression of vascular endothelial growth factor in nasal polyp and chronic rhinosinusitis

background: nasal inflammatory disorders such as chronic rhinosinusitis and nasal polyp are among the most prevalent complications with high socioeconomic costs. vascular endothelial growth factor (vegf) plays a key role in angiogenesis and cell proliferation. in the present study the effect of vegf on the development and prognosis of chronic rhinosinusitis and nasal polyp was investigated. met...

full text

Expression of Vascular Endothelial Growth Factor in Nasal Polyp and Chronic Rhinosinusitis.

BACKGROUND Nasal inflammatory disorders such as chronic rhinosinusitis and nasal polyp are among the most prevalent complications with high socioeconomic costs. Vascular Endothelial Growth Factor (VEGF) plays a key role in angiogenesis and cell proliferation. In the present study the effect of VEGF on the development and prognosis of chronic rhinosinusitis and nasal polyp was investigated. ME...

full text

Evaluation of Periodontal Disease Effect on the Expression of Vascular Endothelial Growth Factor and Nerve Growth Factor in Dental Pulp

Introduction: Researchers have always been interested in the close and mutual relationship between the pulp and periodontal tissues. Although the effects of pulpal disease on periodontium have been well known, the clear relationship between periodontitis and pulp has not been documented . It seems that bacteria and inflammatory products of periodontitis can affect pulp through accessory canals,...

full text

P-185: Expression and Function of Vascular Endothelial Growth Factor in Fallopian Tuben Carrying Ectopic Pregnancy

Background: Vascular endothelial growth factor (VEGF) is an angiogenic growth factor that is produced by different tissues, including the endometrium and ovary. VEGF is involved in many processes related to reproductive physiology, including angiogenesis, which is essential for implantation and placentation. It has been suggested that VEGF may be the angiogenic factor responsible for the implan...

full text

Deprived TLR9 Expression in Apparently Healthy Nasal Mucosa Might Trigger Polyp-Growth in Chronic Rhinosinusitis Patients

BACKGROUND The origin of nasal polyps in chronic rhinosinusitis is unknown, but the role of viral infections in polyp growth is clinically well established. Toll-like receptors (TLRs) have recently emerged as key players in our local airway defense against microbes. Among these, TLR9 has gained special interest in viral diseases. Many studies on chronic rhinosinusitis with nasal polyps (CRSwNP)...

full text

Serum levels of vascular endothelial growth factor in chronic Obstructive pulmonary disease

  Background :Chronic obstructive pulmonary disease (COPD) is a third leading cause of death.   Methods : In this case control study, we prepared 5 cc bloods from the antecubital vein of 100 COPD patients and 40 healthy individuals as control group. Vascular endothelial growth factor (VEGF) expression protein level was measured by ELISA in both groups.   Results : We found that concentration of...

full text

My Resources

Save resource for easier access later

Save to my library Already added to my library

{@ msg_add @}


Journal title

volume 11  issue 3

pages  231- 237

publication date 2016-07-01

By following a journal you will be notified via email when a new issue of this journal is published.

Hosted on Doprax cloud platform doprax.com

copyright © 2015-2023